GLA and Fabry disease: Seven clinical trials are underway investigating several AAVs encoding the GLA gene for Fabry disease treatment, exploring AAV6 (ClinicalTrials.gov Identifier: NCT04046224 and NCT05039866) and novel modified AAV serotypes based on preclinical studies, including AAVS3, a modified AAV8 variant (ClinicalTrials.gov Identifier: NCT04040049 and NCT04455230).