In this stage, 7 SRPs were associated with risk of AD (Figure 6B; Supplementary Table 3), including: AXL (OR = 0.91, 95% CI: 0.83–0.99, IVW-p = 2.78E-2), CCL5 (OR = 1.15, 95% CI: 1.02–1.30, IVW-p = 2.66E-2), CD55 (OR = 0.89, 95% CI: 0.82–0.97, IVW-p = 1.01E-2), KITLG (OR = 1.23, 95% CI: 1.03–1.46, IVW-p = 2.33E-2), MMP2 (OR = 0.83, 95% CI: 0.70–0.98, IVW-p = 2.85E-2); PLAUR (OR = 1.29, 95% CI: 1.04–1.60, IVW-p = 2.38E-2); SERPINE2 (OR = 0.90, 95% CI: 0.81–0.99, IVW-p = 3.84E-2). The gene discussed is MMP2; the disease is Alzheimer disease.