The 36 up-regulated SRGs in AD brain and the violin plot for them was shown in Figure 4, including PTBP1, SERPINE2, HMGB1, SEMA3F, TNFRSF1A, PGF, GEM, PECAM1, SPP1, IGFBP7, CSF1, IL6ST, JUN, TNFRSF1B, RPS6KA5, FGF2, EGFR, CXCL1, CXCL16, ANGPTL4, HGF, AXL, FGF1, ANGPT1, PTGES, ICAM1, LCP1, SPX, PLAUR, EDN1, SELPLG, CCL2, CXCL12, MMP14, IGFBP5, and CXCL10. The 8 down-regulated SRGs in AD brain and the violin plot for them was shown in Figure 5, including MIF, NRG1, TUBGCP2, IGF1, KITLG, ETS2, INHA, and VGF. This evidence concerns the gene HMGB1 and Alzheimer disease.