TNF and age-related macular degeneration: Saul et al. (2022) also illustrated a dense interaction network encoded by there SRGs, where every gene was highly influenced by other members in this gene set in multiple styles such as ligand-receptor interactions (such as EGF and EGFR) and influence expression or secretion patterns (such as TNFA and IL6). This network of SRGs was considered to facilitate better characterization of senescent cells. Especially, Lei et al. (2024) used this gene set and identified potential biomarkers and drug targets for age-related macular degeneration (AMD), an NDD in the eye.