In the discovery stage, 7 SRPs were associated with risk of AD (Figure 6A; Supplementary Table 2), including: CCL8 (odds ratio [OR] = 0.94, 95% confidence interval [CI]: 0.90–0.99, IVW-p = 1.14E-2), CD55 (OR = 0.86, 95% CI: 0.78–0.94, IVW-p = 1.56E-3), PLAUR (OR = 1.15, 95% CI: 1.01–1.30, IVW-p = 3.04E-2), PAPPA (OR = 0.93, 95% CI: 0.87–1.00, IVW-p = 4.43E-2), SERPINE2 (OR = 0.91, 95% CI: 0.84–0.99, IVW-p = 2.74E-2), TNFRSF1A (OR = 0.88, 95% CI: 0.79–0.99, IVW-p = 3.74E-2), VEGFA (OR = 0.95, 95% CI: 0.90–1.00, IVW-p = 4.21E-2). The gene discussed is PAPPA; the disease is Alzheimer disease.