SERPINE2 and type 2 diabetes mellitus: In addition, SERPINE2 is associated with coagulation and cholesterol homeostasis, whose mutations show pleiotropic effects on blood-cell-related traits such as platelet count, metabolic traits such as levels of lipoprotein and lipid, and on disease traits such as coronary artery disease and type 2 diabetes (Nath et al., 2019).