In the management of poor hypertension, the combination of two antihypertensive drugs (such as angiotensin-converting enzyme inhibitors or angiotensin receptor blockers with calcium channel blockers or beta-blockers) is 2–5 times more effective in lowering blood pressure and may reduce cardiovascular complications compared to increasing the dose of a single drug, such as acute coronary syndrome (29% vs. 40%) and stroke (40% vs. 54%).20,21. This evidence concerns the gene ACE and Stroke.