IGF1 and Alzheimer disease: The implementation of patterning factors, including PDGF-AA, insulin-like growth factor 1 (IGF-1), and thyroid hormone (T3) during cortical organoid generation have increased myelinating oligodendrocyte populations in brain organoids as early as day 50, however myelinated organoids have yet to be used to investigate the role of oligodendrocytes in AD etiology and progression (Madhavan et al., 2018; Marton et al., 2019; Shaker et al., 2021).