Increased cleaved CASP3 in AD-E4 and decreased synaptophysin and PSD95 in AD at 12 weeks. Increased organoid maturation in AD around 4 weeks. Increased Aβ42, Aβ40, and Aβ42/Aβ40 in AD at 12 weeks. Increased p-tau (AT8) and soluble apoE in Con-E4, AD-E3, and AD-E4. Enrichment of gene sets involved in RNA metabolisms affected in AD. Here, APOE is linked to Alzheimer disease.