The adenosine-to-inosine (A-to-I) editing mediated by the adenosine deaminase acting on RNA (ADAR) protein family (Gallo et al., 2017) in mammals plays an important function in neurodevelopment and neuropsychiatric diseases (Krestel and Meier, 2018; Gumpper et al., 2022), such as amyotrophic lateral sclerosis (ALS), developmental epileptic encephalopathy, and depression (Yang et al., 2021). The gene discussed is ADAR; the disease is amyotrophic lateral sclerosis.