GLS and neoplasm: Currently, multiple studies have found that miR-141-3p can influence cell proliferation and modulate immune cell functions, playing a significant role in tumor immunity.45, 46, 47 Yang et al48 demonstrated that miR-141-3p could modulate the intracellular reactive oxygen species via targeting GLS1, then affect malignant phenotype and CD8+ T cell function in bladder cancer microenvironments.48