A significant correlation between concentrations of α-syn and Tau in CSF was observed. Levels of α-syn, t-Tau, and p-Tau increased over two years in the PD group whereas there were no observable changes in the HCs. Those with long disease duration exhibited increases in α-syn and Tau levels. The faster motor decline is linked to an increase in p-Tau over two years. The gene discussed is MAPT; the disease is Parkinson disease.