Furthermore, Rome IV set the criteria for functional gallbladder disorder, which are the same criteria for biliary pain, in addition to the absence of gallstones or other structural pathology and in the presence of supportive criteria in the form of low ejection fraction (EF) on technetium-99 hepatobiliary scintigraphy with cholecystokinin (CCK) stimulation hepatobiliary iminodiacetic acid scan (i.e., CCK-Tc-HIDA scan) abnormal gallbladder emptying is usually defined as a gallbladder EF (GBEF) of less than 35% and normal liver enzymes, conjugated bilirubin, and amylase/lipase [3]. Here, CCK is linked to gallbladder disorder.