Consider ABPA in patients with chronic breathing difficulties (airway limitation) and a pre-existing lung condition like asthma or CF. A positive skin test result for Aspergillus, increased serum IgE (>417 IU/L), fungal-specific IgE and IgG antibodies, and imaging modalities are all part of the diagnostic workup for ABPA [1]. The gene discussed is IGHE; the disease is asthma.