In summary, this research emphasizes the potential of naringin as a cytotoxic and pro-apoptotic phytochemical that modulates the expression of Bcl-2, TGF-β, SMAD2, TNFα, NFκB, BAD, BAX, and caspase-3 genes, ultimately aiding the treatment of oral cancer. Here, SMAD2 is linked to lip and oral cavity carcinoma.