Abbreviations: ECOG, Eastern Cooperative Oncology Group; PS, performance status; PDL1, programmed death ligand 1; ICIs treatment, immune-checkpoint inhibitor treatment after tyrosine kinase inhibitor treatment; ILD, interstitial lung disease; EGFR-TKI, epidermal growth factor receptor-tyrosine kinase inhibitor; TKI, tyrosine kinase inhibitor. The gene discussed is CD274; the disease is interstitial lung disease.