Abbreviations: ECOG, Eastern Cooperative Oncology Group; PS, performance status; PDL1, programmed death ligand 1; ICI treatment, immune checkpoint inhibitor treatment after tyrosine kinase inhibitor treatment; ILD, interstitial lung disease; EGFR-TKI, epidermal growth factor receptor-tyrosine kinase inhibitor; TKI, tyrosine kinase inhibitors. The gene discussed is EGFR; the disease is interstitial lung disease.