Abbreviations: TPS, tumor proportion score; evaluation, initial response evaluation after epidermal growth factor receptor-tyrosine kinase inhibitor treatment; ICIs, immune checkpoint inhibitor treatment after epidermal growth factor receptor-tyrosine kinase inhibitor therapy; discontinuance reason, reasons for discontinuation of epidermal growth factor receptor-tyrosine kinase inhibitor therapy; M, male; F, female; ILD, interstitial lung disease; PD, progressive disease; NE, not valuable; BOR, best overall response; TKI, tyrosine kinase inhibitor. This evidence concerns the gene EGFR and interstitial lung disease.