NLRP3 and inflammatory bowel disease: As the NLRP3 inflammasome has emerged as a crucial regulator of intestinal homeostasis and has been widely associated with the pathogenesis and progression of IBD (Bauer et al., 2010; Liu et al., 2017), and studies have shown that inhibition of the NLRP3 inflammasome is effective for alleviation of IBD (Weber et al., 2023), we investigated the potential activity of SMS on NLRP3 inflammasome signaling.