TNF and Sepsis: We can see that GST-21 significantly reduces serum levels of inflammatory mediators such as TNF-α, IL-6, IL-10, sCD14, and HMGBl and the percentage of TH17 lymphocytes in sepsis, whereas MLA-induced increases in serum cytokine levels, and a decrease in the ratio of Treg/TH17 suggests that blocking CAP leads to intensify the systemic inflammation.