Hence, anti-THY-1 scFv antibodies have been assayed in collagen-induced arthritic mice and demonstrated to suppress the expression of JUNB (the Jun B proto-oncogene) by the has-circ-0094342/miRNA-155-5P/SPI1 axis, thereby deterring the angiogenesis of RA and differentiation of osteoclasts [112]. The gene discussed is JUNB; the disease is rheumatoid arthritis.