Age, sex, age*sex, hypertension, use of antihypertensive drugs, diabetes mellitus, area, central obesity, alcohol consumption habits, smoking habit, sex-smoking habit interaction, BMI, self-report heart disease, hypercholesterolemia, hypertriglyceridemia, physical activity, fibrinogen, apolipoprotein B, and plasminogen. The gene discussed is PLG; the disease is heart disorder.