MAPT and Alzheimer disease: In this study, for the first time, we revealed the potential of RTOP/RTAP/RTPP\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{upgreek}\usepackage{mathrsfs}\setlength{\oddsidemargin}{-69pt}\begin{document}$_{\textrm {AMURA}}$\end{document} as imaging markers for early AD detection by exploiting their WM characterization in subjects with amyloid and possibly tau pathology compared to subject without such a pathology.