MAPT and early-onset autosomal dominant Alzheimer disease: Amyloid-beta (A\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{upgreek}\usepackage{mathrsfs}\setlength{\oddsidemargin}{-69pt}\begin{document}$\beta $\end{document}) accumulation and neurofibrillary tangles due to phosphorylated tau protein define the Alzheimer’s disease (AD) molecular pathology [1].