Dysregulation of long noncoding RNAs (lncRNAs) is thought to be associated with a variety of cancers, including LUAD.8Aquaporin 4 antisense RNA 1 (AQP4-AS1) transcribes an antisense lncRNA of unknown function.9AQP4-AS1 was found to be closely associated with oral squamous cell carcinoma10and the overall survival in gastric cancer.11Moreover, AQP4-AS1 was reported to be a protective factor for NSCLC.12However, in-depth studies on the role of AQP4-AS1 in LUAD are lacking. The gene discussed is AQP4; the disease is cancer.