A previous study reported that AQP4-AS1 was a protective factor for NSCLC.12ALOX15 is a ferroptosis driver gene involved in the pathogenesis of human diseases including cardiovascular and metabolic diseases.22Downregulation of ALOX15 enhances the link between colitis and colorectal carcinogenesis.23Ren et al constructed a signature of ten genes including ALOX15 as a potential novel immunotherapy biomarker for studying LUAD.24These results suggested that AQP4-AS1 and ALOX15 play important roles in LUAD. Here, AQP4 is linked to metabolic disease.