found that the combination of α‐tomatine and curcumin inhibited prostate cancer cell growth, which may be related to the reduction of NF‐κB activity and down‐regulation of its downstream gene, Bcl‐2 in cells and significant down‐regulation of AKT and ERK2/3 phosphorylation. The gene discussed is AKT1; the disease is Familial prostate cancer.