SD treatment significantly down‐regulated p‐PI3K, PI3K, p‐AKT, AKT, mTOR, p‐GSK3β, and β‐catenin while up‐regulating GSK3β and p‐β‐catenin, suggesting that SD may inhibit colon cancer cell growth by regulating AKT/GSK3β/β‐catenin signaling pathway. Here, GSK3B is linked to malignant colon neoplasm.