Tomatine: activates caspase apoptosis signaling pathway, regulates PI3K/AKT pathway, regulates NF‐κB pathway, regulates PERK/eIF2α pathway; α‐Solanine inhibits tumor cell invasion, α‐Tomatine blocks cell cycle progression inhibition, regulates NF‐κB signaling pathway to induce apoptosis. This evidence concerns the gene EIF2AK3 and neoplasm.