found that α‐tomatine inhibits the PI3K/AKT signaling pathway, up‐regulates the pro‐apoptotic protein BAD, and down‐regulates the anti‐apoptotic proteins Bcl‐2/xL, as well as having a synergistic effect with paclitaxel to inhibit prostate cancer. The gene discussed is BCL2; the disease is prostate carcinoma.