Decorin, a protein associated with the ECM, was the most up‐regulated protein of both benign and malignant tumors compared to NSG (log2 fold change of 7.58 and 7.38, respectively) while Biglycan, another ECM component, was the most down‐regulated protein in neoplastic samples compared to NSG (PA and CXPA log2 fold change of −9.96 and −7.29, respectively). This evidence concerns the gene BGN and cancer.