CDH1 and colorectal carcinoma: E-cadherin is an important protein that maintains cell polarity and adhesion connection, and can interact with β-catenin to form complex that play an important role in maintaining the integrity of tissue structure and inhibiting cell migration.25 Decreased expression of E-cadherin may be involved in regulating the occurrence and metastasis of CRC.26 N-cadherin has the opposite effect to E-cadherin.