HLA-C and infection: GLIPH achieves several important goals: (1) It establishes a method for grouping TCR sequences that are likely to recognize the same peptide-MHC combination; (2) It extracts motifs associated with specific antigen interactions, helping to discern vaccination and infection history; (3) It identifies common popular themes among different individuals; (4) It assesses the diversity of T cell responses; and (5) It facilitates analysis of α-β chain T cell responses based on sequence data, independent of antigen and MHC knowledge.