Moreover, bioinformatics analysis revealed that in MCT-PAH rats, there was an upregulation of METTL3, WTAP, and YTHDF1, and the eIF2α mRNA with common sequences of m6A modification was also upregulated, thereby promoting the occurrence and development of pulmonary arterial hypertension [143]. This evidence concerns the gene EIF2A and pulmonary arterial hypertension.