Increased levels of RNA m7G modification mediated by METTL1 were observed in cardiac fibrosis tissue and TGF-β1-induced cardiac fibroblast proliferation, and knocking out METTL1 in fibroblasts alleviated heart failure and cardiac fibrosis induced by myocardial infarction [25]. Here, METTL1 is linked to myocardial infarction.