METTL1 and neoplasm: Under conditions of sublethal heat stress induced by radiofrequency ablation (IRFA), the enhanced translation of SLUG/SNAIL is due to METTL1 and tRNAm7G modification, which inhibits the malignant potential of hepatocellular carcinoma cells [218] and can block the METTL1-TGF-β2-PMN-MDSC axis, promoting anti-tumor immunity and preventing HCC recurrence [219].