Various host cell methylated genes such as SOX1, PAX1, JAM3, EPB41L3, CADM1, and MAL have been investigated for predicting cervical lesions, with PAX1 gene methylation showing the most significant correlation with the progression of cervical intraepithelial neoplasia and cervical cancer occurrence. The gene discussed is JAM3; the disease is cervical intraepithelial neoplasia.