Literature review revealed NLRP3's critical role in PAH, along with TLR2, NFKB1, IL‐1B, HSP90AA1, TNF, TLR4, IL6, IL‐17A, and CASP8, which closely interacted with NLRP3 (Figure 4A). This evidence concerns the gene TLR2 and pulmonary arterial hypertension.