Literature review revealed NLRP3's critical role in PAH, along with TLR2, NFKB1, IL‐1B, HSP90AA1, TNF, TLR4, IL6, IL‐17A, and CASP8, which closely interacted with NLRP3 (Figure 4A). Here, HSP90AA1 is linked to pulmonary arterial hypertension.