Literature review revealed NLRP3's critical role in PAH, along with TLR2, NFKB1, IL‐1B, HSP90AA1, TNF, TLR4, IL6, IL‐17A, and CASP8, which closely interacted with NLRP3 (Figure 4A). The gene discussed is IL1B; the disease is pulmonary arterial hypertension.