For instance, TXNIP, which includes cg19693031 (chosen in 43 DNAm-metabolomics models), was previously associated to hyperglycaemia and insulin resistance, and ABCG1, nearby cg06500161 (in 42 DNAm-metabolomics models) was associated to plasma lipid levels and stroke (Fig. 6d). The gene discussed is TXNIP; the disease is Insulin resistance.