Notably, these correlations might suggest a link between the metabolome and protein markers related to immune signalling (LTα, CD6, CCL21, SELE), energy balance and metabolism-related hormones (IGFBP1, SHGB, ADM, leptin, and STC1), and atherosclerosis/thrombosis inhibitor (PAI1). The gene discussed is SERPINE1; the disease is atherosclerosis.