Conversely, HYD effectively decreased body weight and liver weight (Figures 3(f) and S3E), mitigated hepatic lipid deposition and lipid metabolic disorder (Figures 3(g–i)), and improved the condition of epididymal adipose tissue (Figure S3H-I) in HFD mice, suggesting that inhibition of hepatic AOX1 might be a potential therapeutic strategy for NAFLD. The gene discussed is AOX1; the disease is Disorder of lipid metabolism.