Notably, fusion genes such as PAX3–FOXO1 (found in alveolar rhabdomyosarcoma) and EWS-ETS (found in primitive neuroectodermal tumor or Ewing sarcoma) can intentionally trigger the expression of PDGF family members through experimental means [98, 99]. Here, FOXO1 is linked to alveolar rhabdomyosarcoma.