In line with its enrichment in striated muscles, CAP2−/− mice displayed skeletal muscle and cardiac defects [13, 18, 34, 45, 69], and human genetic studies associated pathogenic CAP2 variants with nemaline myopathy or dilated cardiomyopathy [5, 12, 24, 55]. Here, CAP2 is linked to dilated cardiomyopathy.