CAP1 and Charcot-Marie-Tooth disease, axonal, type 2FF: Interestingly, the INF2 inhibitory KAc-actin/CAP complex has been initially purified from mouse brain, and disease-linked INF2 mutations (including mutations linked to Charcot-Marie-Tooth neuropathy) were only poorly inhibited by this complex [2], suggesting a disease contribution of this interaction [3].