Although there are other mouse lines showing inducible Cre expression in microglia such as HEXB-CreERT2 [14], TMEM119-CreERT2 [15] and P2RY12-CreERT [2, 13] as well as binary Cre models [44], they are less efficient in recombining all microglia [45] and their utility in the context of infectious and non-infectious encephalitis models remains to be proven. Here, HEXB is linked to infectious encephalitis.