Ten DEGs, namely TPM1, EIF2S3, CCN2, ACTN1, ACTG2, CCN1, CSRP1, EIF1AX, BEX2 and TCEAL5, were identified as hub‐DEGs, presumably playing critical roles in HD development out of a total of 1743 DEGs. Here, ACTN1 is linked to Huntington disease.