Dex could reverse the up-regulated expression of low-density lipoprotein receptor-related protein 1b(Lrp1b) and DNA damage-regulated autophagy modulator 2(Dram2) while down-regulating the expression of miR-27A-3p, thereby inhibiting excessive autophagy and ameliorating the neurological damage caused by brain injury [64]. This evidence concerns the gene DRAM2 and injury.