Using this cut off value, tumours with high NOTCH1 mRNA expression were more likely HR negative (OR 2.1, 95% CI 1.20–3.77, p = 0.009, Supplementary Table S3) and more likely HER2 positive (OR 3.3, 95% CI 1.89–5.61, p < 0.001) than those with low expression. The gene discussed is ERBB2; the disease is neoplasm.