ADAM19 and chronic obstructive pulmonary disease: Among these, variants in a disintegrin and metalloproteinase domain 19 (ADAM19) have been consistently associated with forced expiratory volume in the first second (FEV1) [3, 4], the ratio of FEV1 to forced vital capacity (FVC) [1–3, 5–8], peak expiratory flow (PEF) [3, 4], and COPD [9, 10].