SOX2 and central nervous system cancer: They analyzed The Glioma French, the Cancer Genome Atlas (TCGA), and the Chinese Glioma Genome Atlas datasets, reporting that the expression of Twist 1 [a gene that stimulates the stemness markers such as BMI1, CRIPTO1, DPPA2, KLF4, and SOX2 in CSC [61]] is related to a poor prognosis in GB patients.