Research in cell lines has revealed that TFPI-2 is correlated with lower invasiveness of GBM SNB19 [43, 70] human lung cancer A549 [71], prostate cancer LNCaP [52], fibrosarcoma HT-1080 [72], pancreatic ductal adenocarcinoma [49], gastric cancer (GC) [73], BC [74]), amelanotic melanoma C-32 [75] and thyroid cancer [76] cells. The gene discussed is TFPI2; the disease is Familial prostate cancer.