Wong et al. (2007) demonstrated that the TFPI-2 gene in HCC is frequently silenced not only by promoter methylation, but also as a result of histone deacetylation, and that expression of the gene in HCC cell lines could be restored by a combined treatment with 5-Aza-dC and histone deacetylase inhibitor – tricostatin [50]. This evidence concerns the gene TFPI2 and hepatocellular carcinoma.