Increased LH levels in women with PCOS stimulate the ovarian production of androgen precursors (DHEA-S and A4-dione) by the theca cells and therefore lead to increased serum TST levels and FAI giving rise to the symptoms of hyperandrogenism such as hirsutism, acne and androgenic alopecia (Rachoń, 2012). The gene discussed is PLOD1; the disease is acne.