Serum concentrations of LH, PRL, DHEA-S, A4-dione, and TST were significantly higher in women with PCOS (p = 0.023, p = 0.008, p < 0.001, p = 0.002 and p = 0.006, respectively) whereas serum concentrations of SHBG were significantly lower compared to the control subjects (p = 0.010). This evidence concerns the gene SHBG and polycystic ovary syndrome.