Moreover, certain HERV Env proteins may even exert pathogenic functions, such as the HERV‐K (HML‐2) Env in amyotrophic lateral sclerosis166 and in aging‐related inflammation,167 HERK‐W Env‐derived Syncytin 1 in multiple sclerosis,168 and HERV‐K (HML‐2) Env and Syncytin 1 in neurodegenerative diseases.169. This evidence concerns the gene ERVW-1 and neurodegenerative disease.