One newly identified significant locus from our analysis is the well-known AD risk gene, APOE. We observed a significant association between the APOE ε2 haplotype and an elevated risk of PSP (P = 9.57 × 10–16, β = 0.87, MAF = 0.06, Table 2, Fig. S3B). The gene discussed is APOE; the disease is supranuclear palsy, progressive, 1.