SP1 and supranuclear palsy, progressive, 1: This, along with our recent work identifying a neuronally-enriched transcription factor network centered around SP1 disrupted by PSP common genetic risk, suggests that although PSP neuropathologically is defined by tufted astrocytes and oligodendroglial coiled bodies [6, 89, 90], initial causal drivers of PSP appear to be primarily neuronal.