We also found that in patients with PAAD, TRPV1 DNA methylation was associated with disease-free interval (DFI), DSS, PFS, and OS (Fig. 6E); SNORA12 DNA methylation was related to PFS, PFS, and OS; and ITGB4 DNA methylation was associated with DFI, PFS, and OS (Fig. 6E). The gene discussed is ITGB4; the disease is pancreatic adenocarcinoma.