Shrimp depend entirely on innate immune responses against pathogenic infections through cellular and humoral responses, such as prophenoloxidase (proPO) activation, toll pathway initiation, hemolymph coagulation, complement activation, melanization, phagocytosis, encapsulation, and antimicrobial peptide synthesis interceded by serine proteinase cascades [80–82]. Here, TLR4 is linked to infection.