We compared baseline characteristics between the non-medication-changes and medication-changes groups, identifying significant differences in the following variables: age, BMI, SBP, DBP, HbA1c, UACR, HDL-C, TG, past medical history or comorbidity (hypertension and retinopathy), and medication use (SGLT-2 inhibitors, GLP-1 RAs, metformin, dipeptidyl peptidase-4 [DPP-4] inhibitors, RAS inhibitors, calcium channel blockers, and/or thiazide). This evidence concerns the gene SLC5A2 and hypertensive disorder.