Through examination of several vaccine strains of influenza A (H1N1, H3N2, H5N1, H7N9) and influenza B derived from mammalian Madin-Darby Canine Kidney (MDCK) cells, human embryonic retinal cells (Per C6) and embryonated chicken eggs, we have identified a widespread distribution of early-stage hexose-glycated lysines exclusively presented in matrix 1 (M1), hemagglutinin (HA) and neuraminidase (NA) surrounding the influenza envelop membrane. This evidence concerns the gene XK and influenza.