NTRK1 and hereditary sensory and autonomic neuropathy: Incomplete glycosylation of the neurotrophin receptor TrkA, as is commonly observed in Hereditary sensory and autonomic neuropathy-associated TrkA variants80, is associated with an immature, lower molecular weight protein that prematurely exits the cellular sorting system before reaching the plasma membrane and is thereby unable to activate the Ras-MAP kinase pathway60,81.