PNLIP and cystic fibrosis: Exocrine pancreatic insufficiency (EPI) is a condition characterized by a deficiency of exocrine pancreatic enzymes (mainly pancreatic lipase), resulting in the inability to digest food properly, or maldigestion.[1] A number of pancreatic disorders and clinical conditions can cause EPI, including but not limited to chronic pancreatitis (CP), pancreatic cancer, pancreatic surgery, and cystic fibrosis (CF), in addition to extra-pancreatic disorders such as diabetes mellitus and inflammatory bowel disease.[1,2]