The researchers proposed that supraclavicular lymph node dissection may be an effective means of local control for estrogen receptor negative, progesterone receptor negative breast cancer patients with initial supraclavicular lymph node metastasis, but may be detrimental to the overall survival of human epidermal growth factor receptor-2 negative breast cancer patients with initial supraclavicular lymph node metastasis. This evidence concerns the gene ESR1 and breast carcinoma.