Of the 8 genes that make up the GRS formula, FEZ1 is a tumor suppressor gene in breast cancer associated with microtubule components, and it can inhibit cancer cell growth by regulating mitosis in breast cancer.[22] The inhibition mechanism in breast cancer may be related to the downregulation of the promoter.[23] The SI gene encodes a protein encoding the sucrase-isomaltase protein that is expressed in the intestinal brush margin, which plays an important role in the carbohydrate absorption function of the intestinal epithelium. Here, SI is linked to breast carcinoma.