ART4 and breast cancer: Tumor-associated glycosphingolipids have been used as immunotherapeutic targets and diagnostic markers for cancers.[32] In recent years, many studies have shown that, as tumor markers, glycosphingolipids can regulate lipid raft and membrane microdomain signaling pathways.[33,34] Glycoproteins are the products of protein glycosylation and are related to the metastasis and invasion of BC.[35] Analysis of glycosylation changes can be used to identify relevant BC biomarkers.[36,37]