Italian guidelines recommend a single dose of intravenous methylprednisolone pulse together with IVIG and aspirin in high-risk patients (age < 1 year, CRP > 200 mg/L, severe anemia at disease onset, liver disease, albumin < 2.5 g/dL, overt CAA, septic shock or macrophage activation syndrome).[47] The low incidence of FNP in KD patients makes it difficult to systematically evaluate the risk of CAA. The gene discussed is CRP; the disease is liver disorder.