Western blot analysis revealed that in the LPS-induced sepsis model (Group 2), Nogo-A expression was significantly elevated, while the expression of proteins such as p-PERK, MFN1, NOX2, NOX4, NLRP3, p-STING, p-TBK1, and IL-1β also significantly increased, and SHP2 expression decreased. The gene discussed is NOX4; the disease is Sepsis.