In the comparison between Group 2 and Group 1, Nogo-A expression was higher, with significant differences; expressions of p-PERK, MFN1, NOX2, NOX4, NLRP3, PINK, Parkin, p-STING, p-TBK1, and IL-1β were higher, indicating that sepsis elevates Nogo-A expression and promotes the expression of these proteins, while SHP2 expression was lower, indicating that Nogo-A inhibits SHP2 expression. This evidence concerns the gene TBK1 and Sepsis.