This suggests that gliosis in cerebral malaria indicates an early response to vascular injury (53), and the net decrease in neuronal transcripts in circulating EVs may indicate gradual neuronal hypofunction with disease progression rather than neuronal death (54), except in extremely severe cases (41) as the body temporarily suspends most of the homeostatic functions to prioritize adaptive prosurvival functions such as those promoted by synaptic glutamatergic and neurotrophins signaling (38, 55). This evidence concerns the gene BDNF and cerebral malaria.