More recent studies have documented instances of microbiota dysbiosis in patients infected with SARS-CoV-2 (COVID-19).145 Similarly, mice carrying COVID-19 exhibited reduced microbial diversity and significant alterations in intestinal epithelial composition.145 Notably, severely ill mice showed diminished Paneth cell numbers, along with abnormalities in granule placement and morphology, coupled with reduced gene expression of antimicrobial factors such as lysozyme and defensins.145 These changes to the Paneth cells are reminiscent of changes seen in human cases of IBDs. Here, LYZ is linked to COVID-19.