We envision a possible mechanism that in the process of inflammation-related colorectal carcinogenesis via DNA damage through HMGB1-TLR4/RAGE-NF-κB signaling pathways, Tregs, and CTLs, activated by DC-mediated tumor antigen presentation, are accumulated in spleen, and GL inhibits them (Fig 8). Here, TLR4 is linked to neoplasm.